BRIAN KOBILKA, M.D.
Osteopathic Medicine in Palo Alto, CA
License number
California G68848
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
279 Campus Dr Beckman Ctr ROOM 157, Palo Alto, CA 94305
Phone
(650) 723-7069
Organization information
See more information about BRIAN KOBILKA at bizstanding.comBrian Kobilka MD
279 Campus Dr, Stanford, CA 94305
Industry:
Internist
Phone:
(650) 723-7069 (Phone)
Brian Kent Kobilka
Professional information
Method For Obtaining G Protein-Coupled Receptor (Gpcr) Diffraction-Quality Crystals Employing A Monoclonal Antibody That Binds To The Third Intracellular Loop (Il3)
US Patent:
7947807, May 24, 2011
Filed:
Sep 19, 2008
Appl. No.:
12/284245
Inventors:
Brian Kobilka - Palo Alto CA, US
Dan Rohrer - Los Gatos CA, US
Peter Brams - Sacramento CA, US
Asna Masood - Saratoga CA, US
Dan Rohrer - Los Gatos CA, US
Peter Brams - Sacramento CA, US
Asna Masood - Saratoga CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07K 14/00, C12P 21/08, B01D 9/00
US Classification:
530350, 53038822, 23300
Abstract:
An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
Protein Binding Domains Stabilizing Functional Conformational States Of Gpcrs And Uses Thereof
US Patent:
2013013, May 30, 2013
Filed:
Jul 18, 2011
Appl. No.:
13/810657
Inventors:
Jan Steyaert - Beersel, BE
Els Pardon - Lubbeek, BE
Toon Laeremans - Dworp, BE
Søren Rasmussen - Gentofte, DK
Brian Kobilka - Palo Alto CA, US
Juan Fung - San Jose CA, US
Els Pardon - Lubbeek, BE
Toon Laeremans - Dworp, BE
Søren Rasmussen - Gentofte, DK
Brian Kobilka - Palo Alto CA, US
Juan Fung - San Jose CA, US
International Classification:
G01N 33/68
US Classification:
5303873, 436501, 506 9, 435 792
Abstract:
The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
Method And Composition For Crystallizing G Protein-Coupled Receptors
US Patent:
8637639, Jan 28, 2014
Filed:
Mar 30, 2012
Appl. No.:
13/436709
Inventors:
Brian Kobilka - Palo Alto CA, US
Daniel Rosenbaum - Burlingame CA, US
Daniel Rosenbaum - Burlingame CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07K 14/705, C07K 19/00, C12N 15/62
US Classification:
530350, 435 697, 536 234
Abstract:
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
Soluble 7-Transmembrane Domain G-Protein-Coupled Receptor Compositions And Methods
US Patent:
5925549, Jul 20, 1999
Filed:
Apr 14, 1997
Appl. No.:
8/837151
Inventors:
Aaron J. W. Hsueh - Stanford CA
Brian K. Kobilka - Palo Alto CA
Masataka Kudo - Menlo Park CA
Brian K. Kobilka - Palo Alto CA
Masataka Kudo - Menlo Park CA
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Stanford CA
International Classification:
C07K 14705, C07K 1628, C12N 1562
US Classification:
435 697
Abstract:
Chimeric polypeptides containing the N-terminal amino acid sequence of a glycoprotein hormone receptor polypeptide and a membrane anchor polypeptide, with a protease recognition site between the two, are disclosed. Also disclosed are nucleic acids encoding such polypeptides, expression vectors containing such nucleic acids and methods of producing such recombinant chimeric polypeptides, as well as uses thereof. The chimeric polypeptides are particularly useful for the production of soluble glycoprotein hormone receptor polypeptides.
Synthetic Amphiphiles For Membrane Protein Manipulation
US Patent:
2013032, Dec 5, 2013
Filed:
Aug 7, 2013
Appl. No.:
13/961757
Inventors:
Brian KOBILKA - Palo Alto CA, US
Soren RASUMSSEN - Gentofte, DK
Soren RASUMSSEN - Gentofte, DK
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Wisconsin Alumni Research Foundation - Madison WI
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07H 15/04, C07K 1/14
US Classification:
530412, 536 179, 536 41
Abstract:
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.
Synthetic Amphiphiles For Membrane Protein Manipulation
US Patent:
8530631, Sep 10, 2013
Filed:
Mar 24, 2010
Appl. No.:
12/731000
Inventors:
Samuel Helmer Gellman - Madison WI, US
Pil Seok Chae - Madison WI, US
Brian Kobilka - Palo Alto CA, US
Soren Rasmussen - Palo Alto CA, US
Pil Seok Chae - Madison WI, US
Brian Kobilka - Palo Alto CA, US
Soren Rasmussen - Palo Alto CA, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07H 15/02, C07H 15/04
US Classification:
536 41, 536 179
Abstract:
The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.
Crystal Structure Βadrenoreceptor
US Patent:
7912654, Mar 22, 2011
Filed:
Sep 16, 2008
Appl. No.:
12/283988
Inventors:
Brian K. Kobilka - Palo Alto CA, US
Gebhard F. X. Schertler - Cambridge, GB
Gebhard F. X. Schertler - Cambridge, GB
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Heptares Therapeutics Limited - Welwyn Garden, Hertfordshire
Heptares Therapeutics Limited - Welwyn Garden, Hertfordshire
International Classification:
G01N 33/50, G01N 33/00
US Classification:
702 19, 702 27, 436 86
Abstract:
A computer readable medium comprising atomic coordinates for the human βadrenoreceptor is provided. The computer readable medium programming for displaying a molecular model of the human βadrenoreceptor, programming for identifying a compound that binds to said human βadrenoreceptor and/or a database of structures of known test compounds. Also provided is a method comprising computationally identifying a compound that binds to the human βadrenoreceptor using the atomic coordinates.
Amphiphilic Compounds
US Patent:
2013026, Oct 10, 2013
Filed:
Mar 14, 2013
Appl. No.:
13/826466
Inventors:
Pil Seok Chae - Ansan, KR
Brian Kobilka - Palo Alto CA, US
Soren Rasmussen - Beersel, BE
Brian Kobilka - Palo Alto CA, US
Soren Rasmussen - Beersel, BE
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION - Madison WI
International Classification:
C07J 17/00, A61K 9/107, C07J 41/00
US Classification:
424490, 536 5, 536 6, 514 11, 530422, 25218212, 530350
Abstract:
Bringing membrane proteins into aqueous solution generally requires the use of detergents or other amphiphilic agents. The invention provides a new class of amphiphiles, each of which includes a multi-fused ring system as a lipophilic group. These new amphiphiles confer enhanced stability to a range of membrane proteins in solution relative to conventional detergents, leading to improved structural and functional stability of membrane proteins, including integral membrane proteins. Accordingly, the invention provides new amphiphiles for biochemical manipulations and characterization of membrane proteins. These amphiphiles display favorable behavior with membrane proteins and can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
Gpcr Comprising An Ic2 Insertion
US Patent:
8470561, Jun 25, 2013
Filed:
Aug 29, 2011
Appl. No.:
13/220513
Inventors:
Brian Kobilka - Palo Alto CA, US
Assignee:
ConfometRX Inc. - Palo Alto CA
International Classification:
C12P 21/04, C07K 14/00
US Classification:
435 697, 530350
Abstract:
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.
Method And Composition For Crystallizing G Protein-Coupled Receptors
US Patent:
7790850, Sep 7, 2010
Filed:
Oct 15, 2008
Appl. No.:
12/288097
Inventors:
Brian Kobilka - Palo Alto CA, US
Daniel Rosenbaum - Burlingame CA, US
Daniel Rosenbaum - Burlingame CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07K 14/705, C07K 19/00, C12N 15/62
US Classification:
530350, 435 697, 536 234
Abstract:
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.