Inventors:
Brian K. Roberts - Palo Alto CA, US
Gopal Chandra Saha - Dublin CA, US
Brian Edward Lavan - San Francisco CA, US
Charles A. McWherter - Oakland CA, US
International Classification:
A61K 31/519, A61K 31/426, A61K 45/06, A61K 31/216
Abstract:
Disclosed herein are pharmaceutical compositions, methods and kits for lowering the serum uric acid level of a subject and for the treatment of a condition associated with elevated serum uric acid levels comprising administering a composition comprising a first urate-lowering agent and a second urate-lowering agent. In some aspects the first urate-lowering agent is (−)-halofenate, (−)-halofenic acid, or a pharmaceutically acceptable salts thereof. In some aspects the second urate-lowering agent is an inhibitor of uric acid production, a uricosuric agent, a uricase, or a pharmaceutically acceptable salt thereof.