BRIAN DAVID JOHNSTON, P.A.
Physician Assistant at Los Gatos Blvd, Los Gatos, CA
License number
California 51974
Category
Nursing
Type
Physician Assistant
Address
Address
2
15400 Los Gatos Blvd, Los Gatos, CA 95032
2350 W. El Camino Real FLOOR 2ND, Mountain View, CA 94040
2350 W. El Camino Real FLOOR 2ND, Mountain View, CA 94040
Phone
(408) 739-6000
Professional information
Antiviral Reagents Based On Rna-Binding Proteins
US Patent:
6063612, May 16, 2000
Filed:
Dec 13, 1991
Appl. No.:
7/808452
Inventors:
Sumedha D. Jayasena - Mountain View CA
Brian H. Johnston - Mountain View CA
Brian H. Johnston - Mountain View CA
Assignee:
SRI International - Menlo Park CA
International Classification:
C12N 700, C07K 1400
US Classification:
4352351
Abstract:
The present invention describes the generation of site-directed RNA cleaving agents. These agents consist of RNA-binding proteins, or polypeptides derived thereof, which are modified to contain a moiety capable of cleaving RNA backbones. Alternatively, the agents are oligonucleotides having nuclease resistant backbones to which a moiety capable of cleaving RNA backbones has been attached. The present invention also describes a method of cleaving target RNA substrates using the cleaving agents described herein. Further, the invention describes a method for inhibiting RNA virus expression in infected cells.