Inventors:
Jenny P.-Y. Ting - Chapel Hill NC, US
Brian P. O'Connor - Denver CO, US
So-Young Eun - San Diego CA, US
Zhengmao Ye - Chapel Hill NC, US
Assignee:
University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A61K 38/00, A61K 38/16, A61P 17/00, A61P 35/00, A61P 35/02
US Classification:
514 11, 514 187, 514 192, 514 193, 514 196, 514 212
Abstract:
The present invention provides methods of reducing or enhancing T cell activation and/or B cell activation in a subject, comprising administering to a subject an effective amount of an inhibitor or enhancer, respectively, of Semaphorin 6D (Sema6D) activity on T cells and/or B cells.