Inventors:
Yifeng Xiong - San Diego CA, US
Martin C. Cherrier - San Diego CA, US
Jin Sun Karoline Choi - San Diego CA, US
Peter I. Dosa - San Diego CA, US
Brian M. Smith - San Diego CA, US
Brett Ullman - San Diego CA, US
Bradley Teegarden - San Diego CA, US
International Classification:
A61K 31/497, C07D 403/06, C07D 403/14, A61P 25/20, A61P 7/02, A61P 7/12, A61P 9/12, A61P 29/00
Abstract:
Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HTreceptor. Formula (Ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de Ia Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HTserotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.