Inventors:
Brett P. Giroir - Dallas TX, US
Monty S. Willis - Dallas TX, US
Timothy S. Church - Dallas TX, US
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 33/53, C12Q 1/00, C07K 1/00
Abstract:
Macrophage migration inhibitory factor (MIF) is a clinically useful biochemical marker of cardiovascular risk. Risk assessment includes the step of detecting in the blood of a person MIF concentration as a marker of cardiovascular risk for the person. The method may further comprise the step of assigning to the person a cardiovascular risk metric proportional to the MIF concentration, and/or prescribing for the person a cardiovascular treatment modality in accordance with the MIF concentration. The method is useful as a primary screen, and may be used in conjunction with or as a substitute for additional tests, such as a stress test, CRP assay, LDL assay, etc. The detecting step may be repeated over time intervals and/or treatment to monitor change in cardiovascular risk for the person over time and/or treatment.