DR. BRANDON GREER BUSBEE, M.D.
Medical Practice at 23 Ave, Nashville, TN

2008002, Jan 24, 2008

Jul 24, 2006

11/491611

Abu Alam - Lake Forest IL, US
Elias Reichel - Weston MA, US
Brandon Busbee - Nashville TN, US

Akorn, Inc. - Buffalo Grove IL

A61K 31/27, A61K 31/16

514331, 514485, 514626

Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.

2008002, Jan 24, 2008

May 7, 2007

11/745207

Abu Alam - Lake Forest IL, US
Elias Reichel - Weston MA, US
Brandon Busbee - Nashville TN, US

Akorn, Inc. - Buffalo Grove IL

A61K 9/16

424486

Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.

2013032, Dec 5, 2013

Aug 7, 2013

13/961453

Elias Reichel - Weston MA, US
Brandon Busbee - Nashville TN, US

Akorn, Inc. - Lake Forest IL

A61K 9/00, A61K 31/167

514626

Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.

2012003, Feb 9, 2012

Oct 20, 2011

13/277946

Abu Alam - Lake Forest IL, US
Elias Reichel - Weston MA, US
Brandon Busbee - Nashville TN, US

AKORN, INC. - Lake Forest IL

A61K 9/14, A61K 31/16

424488, 514626

Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.

2009012, May 14, 2009

Jan 15, 2009

12/354422

ABU ALAM - Lake Forest IL, US
Elias Reichel - Weston MA, US
Brandon Busbee - Nashville TN, US

Akorn, Inc. - Lake Forest IL

A61K 31/167, A61K 9/00, A61K 31/445, A61K 31/24, A61F 13/00, A61P 25/00

424449, 514626, 424484, 514330, 514535

Disclosed is a method of inducing topical anesthesia in a tissue or organ of an animal comprising providing an aqueous gel formulation comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed are a transdermal patch comprising the aqueous gel formulation suitable for applying on the skin of a patient and a method of controlling pain therewith.