Brack Gillium Hattler, JR
Physician at 5 Ave, Pittsburgh, PA

2006026, Nov 23, 2006

Apr 21, 2006

11/408576

Brack Hattler - Pittsburgh PA, US
William Federspiel - Pittsburgh PA, US
Brian Frankowski - Imperial PA, US

A61M 37/00

604026000

A compact,intravenous, percutaneous respiratory assist catheter having a rotating fiber bundle functions as an intravenous oxygenerator configured to be implanted within the patient's vasculature. The respiratory assist catheter provides oxygen introduction and carbon dioxide removal from the blood of the patient. the catheter includes hollow, gas-permeable fibers extending between a distal manifoldand a proximal manifold that permit diffusion of gases between the blood vessel and the interior of the fibers. An implantable version of the catheter is configured with a fiber bundle having increased porosity and with a mechanism to prevent the fiber bundle from damaging the vena cava. The fiber bundle may be protected by a wire loom or coil cage made from materials such as nitinol and stainless steel. The rotation of the fiber bundle may be varied in speed and in direction.

5376069, Dec 27, 1994

Apr 30, 1993

8/056127

Brack G. Hattler - Pittsburgh PA

A61M 3700

604 26

An inflatable percutaneous oxygenator has an inflatable balloon suitable for insertion into a blood vessel. Oxygen is circulated through a number of gas-permeable passageways (such as hollow gas-permeable fibers) adjacent to the balloon surface to permit diffusion of oxygen and carbon dioxide between the blood vessel and the passageways. Pulsatile flow can be used to increase the rate of cross-diffusion of gases. A pump is used to alternately expand and contract the balloon. This causes movement of the passageways within the blood vessel to minimize streaming or channeling of the blood flow around the oxygenator, maximizes turbulence in the bloodstream, and therefore maximizes diffusion of gases. In one alternative embodiment, the balloon is made of a gas-permeable material and is inflated with oxygen to supplement cross-diffusion of gases with the bloodstream. An external connector with lumens supplies a flow of oxygen to the passageways, exhausts gas from the passageways, and allows inflation and deflation of the balloon by the pump.

5271743, Dec 21, 1993

May 5, 1992

7/878750

Brack G. Hattler - Pittsburgh PA

A61M 3700

604 26

A percutaneous intravenous oxygenator includes a plurality of hollow gas permeable fibers formed into a plurality of loops with one end of the fiber loops being connected to a source of oxygen while the opposite end is connected to a vacuum source. The oxygenator is insertable into a blood vessel such that when oxygen is drawn into the fiber loops, it will diffuse through the walls of the fibers into oxygen deficient blood passing thereby while excess carbon dioxide in the blood will pass in a reverse or cross diffusion pattern through the walls of the fibers into the interior thereof for removal from the fiber loops by the vacuum source. Two separate embodiments for moving the fibers to prevent streaming of blood past the oxygenator are disclosed for optimal cross diffusion of the gases. In one embodiment, a rotatable blade is disclosed within the looped fibers so as to disrupt the linear flow of blood and direct it radially outwardly in convective swirling fashion to keep the fibers moving and optimally disposed for maximum gas diffusion. In the second embodiment, an electromagnet is disclosed within the loops of fibers and the fibers themselves carry a paramagnetic material so that the fibers can be selectively attracted to the rod or actively or passively repelled from the rod again to keep the fibers in motion to prevent streaming of the blood and to optimize the cross transfusion of gases.

5865789, Feb 2, 1999

Jul 23, 1997

8/899018

Brack G. Hattler - Pittsburgh PA

A61M 3700, A61M 2900

604 26

A percutaneous oxygenator is used to induce a retrograde perfusion of oxygenated blood in a vein to a compromised organ (e. g. , to the brain following a stroke, or to the heart following a heart attack). The oxygenator has an occluding balloon and an oxygenation balloon located upstream from the occluding balloon. A plurality of hollow gas-permeable fibers surround the oxygenation balloon. The oxygenator is inserted into a vein downstream from the compromised organ. An external supply of air/oxygen is connected to create a flow through the fibers and thereby oxygenate blood in the surrounding vein. A retrograde flow of oxygenated blood is induced in the vein to the compromised organ by first inflating the occluding balloon to occlude the vein and then inflating the oxygenation balloon. Both balloons are then deflated to permit the normal antegrade flow of blood through the vein. This process of inflation and deflation is periodically repeated at a rate of about 30 to 60 cycles per minute.

4986809, Jan 22, 1991

Feb 26, 1990

7/485299

Brack G. Hattler - Pittsburgh PA

A61M 3700

604 26

A percutaneous oxygenator has a Y-shaped tubular connector and a number of hollow, gas-permeable fibers. One end of each fiber is located in the first upper arm of the connector. The other end of each fiber is located in the other upper arm of the connector, with each fiber forming a loop extending out of the lower opening of the connector. To guide insertion of the device into a patient's vein, and to provide structural support for the fiber loops, a support member extends downward from the connector with an aperture at is distal end. Each of the fiber loops pass through this aperture. The device is inserted through a single small incision into the patient's venous system. An oxygen supply is attached to one of the upper arms of the connector and flows through the length of the fiber loops. Oxygen and carbon dioxide diffuse across the fiber walls between the blood and the interior of the fiber tubes. In one alternative embodiment, a tip having an interior cavity is secured to the lower end of the support member.

5219326, Jun 15, 1993

May 5, 1992

7/878724

Brack G. Hattler - Pittsburgh PA

A61M 3700

604 26

An inflatable percutaneous oxygenator has an inflatable balloon suitable for insertion into a blood vessel. Oxygen is circulated through a number of gas-permeable passageways (such as hollow gas-permeable fibers) adjacent to the balloon surface to permit diffusion of oxygen and carbon dioxide between the blood vessel and the passageways. Pulsatile flow can be used to increase the rate of cross-diffusion of gases. A pump is used to alternately expand and contract the balloon. This causes movement of the passageways within the blood vessel to minimize streaming or channeling of the blood flow around the oxygenator, maximizes turbulence in the blood stream, and therefore maximizes diffusion of gases. In one alternative embodiment, the balloon is made of a gas-permeable material and is inflated with oxygen to supplement cross-diffusion of gases with the bloodstream. An external connector with lumens supplies a flow of oxygen to the passageways, exhausts gas from the passageways, and allows inflation and deflation of the balloon by the pump.

5122113, Jun 16, 1992

Mar 27, 1991

7/676262

Brack G. Hattler - Pittsburgh PA

A61M 3700

604 26

An inflatable percutaneous oxygenator has an inflatable balloon suitable for insertion into a blood vessel. Oxygen is circulated through a number of gas-permeable passageways (such as hollow gas-permeable fibers) adjacent to the balloon surface to permit diffusion of oxygen and carbon dioxide between the blood vessel and the passageways. A pump is used to alternately expand and contract the balloon. This causes movement of the passageways within the blood vessel to minimize streaming or channeling of the blood flow around the oxygenator, maximizes turbulence in the blood stream, and therefore maximizes diffusion of gases. An external connector has lumens that supply a flow of oxygen to the passageways, exhaust gas from the passageways, and allow inflation and deflation of the balloon by the pump.

5501663, Mar 26, 1996

Jul 2, 1993

8/087487

Brack G. Hattler - Pittsburgh PA
Harvey S. Borovetz - Pittsburgh PA
Gary D. Reeder - Morrison CO
Patricia J. Sawzik - Pittsburgh PA
Frank R. Walters - Pittsburgh PA

Medtronic Electromedics, Inc. - Parker CO

A61M 3700

604 26

An intravenous fiber membrane oxygenator is disclosed in several embodiments wherein the fibers either run at a transverse angle relative to the longitudinal axis of the oxygenator and/or are of a reduced length to optimize the gas transfer efficiency of the oxygenator. Various helical or spiral wraps of fibers are disclosed. One embodiment utilizes two sets of longitudinally extending fibers wherein the oxygen gas is moved in opposite directions from a central location of the oxygenator.

2003013, Jul 17, 2003

Jan 16, 2002

10/052103

Brack Hattler - Pittsburgh PA, US

A61M001/14, A61M037/00

422/045000, 604/006140

An intravenous oxygenator having hollow, gas-permeable fibers extending between a distal manifold and a proximal manifold that permit diffusion of gases between the blood vessel and interior of the fibers A rotatable support member extends through the proximal manifold and into the distal manifold. The support member has a lumen in communication with the distal manifold so that oxygen-containing gases flow through the support member, distal manifold, fibers, and proximal manifold. An impeller is attached to and rotated by the support member to enhance blood flow around the fibers.