Inventors:
Catherine Tachdjian - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Xiao-Qing Tang - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Guy Servant - San Diego CA, US
Qing Chen - San Diego CA, US
Vincent Darmohusodo - Encinitas CA, US
Richard Fine - Ridgewood NJ, US
Joseph R. Fotsing - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Xinshan Kang - Pine Brook NJ, US
Rachel D. A. Kimmich - San Diego CA, US
Boris Klebansky - Demarest NJ, US
Haitian Liu - San Diego CA, US
Goran Petrovic - San Diego CA, US
Jeffrey Yamamoto - San Diego CA, US
Hong Zhang - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Karen Zoller - La Jolla CA, US
Assignee:
Senomyx Inc. - San Diego CA
International Classification:
C07D 239/95, C07D 285/16, A61K 31/517, A61K 31/54
Abstract:
The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e. g. , by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.