DR. BORIS CHRISTIAN BASTIAN, M.D.
Medical Practice at York Ave, New York, NY

6455258, Sep 24, 2002

Apr 13, 2001

09/835181

Boris Bastian - San Francisco CA
Daniel Pinkel - Walnut Creek CA

The Regents of the University of California - Oakland CA

C07H 2104

435 6, 435 912, 536 231

The present invention provides for methods of distinguishing melanocytic nevi, such as Spitz nevi, from malignant melanoma. The methods comprise contacting a nucleic acid sample from a patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region such as 11p, which is usually amplified in Spitz nevi. The nucleic acid sample is typically from skin tumor cells located within a tumor lesion on the skin of the patient. Using another probe which binds selectively to a chromosomal region such as 1q, 6p, 7p, 9p, or 10q, which usually show altered copy number in melanoma, the method can determine that those tumor cells with no changes in copy number of 1q, 6p, 7p, 9p, or 10q, are not melanoma cells but rather Spitz nevus cells. The finding of amplifications of chromosome 11p would be an additional indication of Spitz nevus.

6261775, Jul 17, 2001

Apr 9, 1999

9/288940

Boris Bastian - San Francisco CA
Daniel Pinkel - Walnut Creek CA

The Regents of the University of California - Oakland CA

C12Q 168

435 6

The present invention provides for methods of distinguishing melanocytic nevi, such as Spitz nevi, from malignant melanoma. The methods comprise contacting a nucleic acid sample from a patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region such as 11p, which is usually amplified in Spitz nevi. The nucleic acid sample is typically from skin tumor cells located within a tumor lesion on the skin of the patient. Using another probe which binds selectively to a chromosomal region such as 1q, 6p, 7p, 9p, or 10q, which usually show altered copy number in melanoma, the method can determine that those tumor cells with no changes in copy number of 1q, 6p, 7p, 9p, or 10q, are not melanoma cells but rather Spitz nevus cells. The finding of amplifications of chromosome 11p would be an additional indication of Spitz nevus.

2011021, Sep 8, 2011

May 18, 2011

13/110853

Boris Bastian - New York NY, US
Daniel Pinkel - Lafayette CA, US

The Regents of the University of California - Oakland CA

C12Q 1/68

435 611

This invention provides methods of detecting melanoma. The methods comprises detecting a gain or loss of certain chromosomal regions that undergo copy number changes in melanoma.

7470508, Dec 30, 2008

Sep 9, 2002

10/238116

Boris Bastian - San Francisco CA, US
Daniel Pinkel - Walnut Creek CA, US

The Regents of the University of California - Oakland CA

C07H 21/04, C12Q 1/68

435 6, 435 911, 435 912, 536 231, 536 243

The present invention provides methods of screening for the presence of premalignant melanocytes in a sample from a patient. The methods comprise contacting a nucleic acid sample from a biological sample from the patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is amplified in melanoma cells.

6465180, Oct 15, 2002

Mar 17, 1999

09/271619

Boris Bastian - San Francisco CA
Daniel Pinkel - Walnut Creek CA

The Regents of the University of California - Oakland CA

C12Q 168

435 6, 435 911, 435 912, 435174, 4352831, 4352872, 536 231, 536 243, 536 2433, 536 266

The present invention provides methods of screening for the presence of premalignant melanocytes in a sample from a patient. The methods comprise contacting a nucleic acid sample from a biological sample from the patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is amplified in melanoma cells.

6551780, Apr 22, 2003

Mar 31, 2000

09/541364

Boris Bastian - San Francisco CA
Daniel Pinkel - Walnut Creek CA

The Regents of University of California - Oakland CA

C07H 2104

435 6, 435 912, 536 231

The present invention provides for methods of typing a melanocytic neoplasm, in particular for classifying a Spitz nevus. The methods comprise detecting in a tumor sample the presence of an increase in copy number of the whole chromosome 11p arm, particularly the presence of an 11p isochromosome, which is associated with the presence of a Spitz nevus. The invention further provides methods of typing a melanocytic neoplasm by detecting the presence of a mutated H-RAS gene, which is also associated with the presence of a Spitz nevus.

6783944, Aug 31, 2004

Jan 4, 2002

10/039288

Boris C. Bastian - San Francisco CA

The Regents of the University of California - Oakland CA

C07H 2104

435 6, 435 911, 435 912, 536 231, 536 243, 536 2532

The invention provides methods of distinguishing benign growths arising from congenital melanocytic nevi from malignant melanoma. The methods comprise detecting a change in chromosome number that is specifically associated with benign growths. These changes include a gain of chromosome 10, a gain of chromosome 11, and a loss of chromosome 7.