Arnold L. Smith - Columbia MO Bonnie W. Ramsey - Seattle WA Alan B. Montgomery - Bellevue WA
Assignee:
Pathogenesis Corporation - Seattle WA
International Classification:
A61K 912, A61K 3173
US Classification:
514 38
Abstract:
An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible bacteria. Aminoglycoside formulated in 5 ml solution of a quarter normal saline having pH between 5. 5 and 6. 5. The method for treatment of endobronchial infections by a produced by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5. mu. , produced by a jet or ultrasonic nebulizer.