Inventors:
Russell M. Medford - Atlanta GA
R. Wayne Alexander - Atlanta GA
Sampath Parthasarathy - Atlanta GA
Bobby V. Khan - Dunwoody GA
Assignee:
Emory University - Altanta GA
International Classification:
A61K 3140, A61K 3154, A61K 31265, A61K 31185
Abstract:
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.