Inventors:
Mark E. Meyerhoff - Ann Arbor MI, US
Bruce E. Cohan - Ann Arbor MI, US
Qinyi Yan - Davie FL, US
Bo Peng - Ann Arbor MI, US
Zvi Flanders - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
EYELAB GROUP, LLC - Ann Arbor MI
International Classification:
G01N 27/327
Abstract:
A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.