Inventors:
Bernardino Ghetti - Indianapolis IN, US
Maria Spillantini - Cambridge, GB
Jill Murrell - Avon IN, US
Michel Goedert - Cambridge, GB
Martin Farlow - Indianapolis IN, US
Aaron Klug - Cambridge, GB
Assignee:
Advanced Research and Technology
International Classification:
C12Q001/68, G01N033/567, G01N033/53, G01N033/537, G01N033/543
US Classification:
435/006000, 435/007210, 435/007920
Abstract:
The present invention relates generally to methods and compositions for the diagnosis, modeling and treatment of tau-related pathologies. In particular, the present invention shows that mutations in the tau gene lead to neurofibrillary tangle formation. More specifically gene mutations are described that lead to alterations in ratios of tau isoforms are shown to lead to the formation of abnormal tau filaments.