DR. BERNARD L SILVERMAN, M.D.
Medical Practice at Charles River St, Needham, MA
License number
Massachusetts 212003
Category
Medical Practice
Type
Pediatric Endocrinology
Address
Address
311 Charles River St, Needham, MA 02492
Phone
(617) 583-6350
Personal information
See more information about BERNARD L SILVERMAN at radaris.comName
Address
Phone
311 Charles River St, Needham, MA 02492
37 Francis St, Revere, MA 02151
420 Revere Beach Blvd, Revere, MA 02151
Organization information
See more information about BERNARD L SILVERMAN at bizstanding.comBernard L Silverman MD
311 Charles Riv St, Needham, MA 02492
Categories:
Endocrinology & Metabolism Physicians & Surgeons, Pediatrics Physicians & Surgeons
Phone:
(617) 583-6350 (Phone)
Professional information
See more information about BERNARD L SILVERMAN at trustoria.com
Peripherially Acting Μ Opioid Antagonists
Peripherially Acting Μ Opioid Antagonists
US Patent:
2012024, Sep 27, 2012
Filed:
Feb 14, 2012
Appl. No.:
13/396152
Inventors:
Bernard Silverman - Needham MA, US
Mark Todtenkopf - Franklin MA, US
Daniel Deaver - Franklin MA, US
Lauren DiPetrillo - Somerville MA, US
Mark Todtenkopf - Franklin MA, US
Daniel Deaver - Franklin MA, US
Lauren DiPetrillo - Somerville MA, US
International Classification:
A61K 31/485, C07D 221/28, C07D 489/08, A61P 1/00
US Classification:
514282, 514289, 546 74, 546 45
Abstract:
The present invention relates to a novel functional peripherally-acting μ opioid receptor antagonist of Formula I:The novel compounds of the present invention have reduced oral bioavailability without compromising opiate-induced analgesia in the CNS. The compounds of the present invention are further efficacious at low doses and are useful in treating gastrointestinal conditions associated with opioid analgesic therapy.
Morphinan Derivatives For The Treatment Of Drug Overdose
Morphinan Derivatives For The Treatment Of Drug Overdose
US Patent:
2011013, Jun 9, 2011
Filed:
Oct 13, 2010
Appl. No.:
12/903462
Inventors:
Bernard Silverman - Needham MA, US
International Classification:
A61K 31/485, A61K 31/4748, A61P 25/36
US Classification:
514282, 514289
Abstract:
The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose: