BERNARD ALEXANDER RAWLINS
Pilots at Johnson Ave, Englewood, NJ
License number
New Jersey A4743817
Issued Date
Jan 2017
Expiration Date
Jan 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
22 Johnson Ave, Englewood, NJ 07632
Professional information
Method Of Enhancing Bone Density
US Patent:
6939540, Sep 6, 2005
Filed:
Jul 31, 2000
Appl. No.:
09/629074
Inventors:
Ronald G. Crystal - Potomac MD, US
Chisa Hidaka - New York NY, US
Oheneba Boachie-Adjei - New York NY, US
Bernard A. Rawlins - Englewood NJ, US
Imre Kovesdi - Rockville MD, US
Chisa Hidaka - New York NY, US
Oheneba Boachie-Adjei - New York NY, US
Bernard A. Rawlins - Englewood NJ, US
Imre Kovesdi - Rockville MD, US
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
The Hospital for Special Surgery - New York NY
GenVec, Inc. - Gaithersburg MD
The Hospital for Special Surgery - New York NY
GenVec, Inc. - Gaithersburg MD
International Classification:
A01N063/00, A01N043/04, A61K048/00, C12N005/00, C12N015/00
US Classification:
424 932, 424 931, 424 9321, 4353201, 435325, 435455, 514 44
Abstract:
The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding an osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.