Benno Maxim Guggenheimer
Engineers at City Park, Fort Collins, CO

6809823, Oct 26, 2004

Sep 28, 2001

09/967451

William P Kennedy - Loveland CO
John Bernard Medberry - Windsor CO
David Washburn - Fort Collins CO
Benno Guggenheimer - Fort Collins CO
James D Adams - Boulder CO

Agilent Technologies, Inc. - Palo Alto CA

G01B 1100

356400, 25022727

An optical system for detecting and coupling light to optical devices, and a method for aligning and calibrating the system. The system includes positioning stages and fiber sensors. The fiber sensors are used to detect the positions of calibration pieces and other sensors in a variety of configurations. From these detected positions, any misalignment of the sensors or positioning stages may be calculated and corrected for. The fiber sensors calibrate the system.

6778740, Aug 17, 2004

Jul 31, 2002

10/208873

John Bernard Medberry - Windsor CO
Benno Guggenheimer - Fort Collins CO

Agilent Technologies, Inc. - Palo Alto CA

G02B 626

385 52, 385 15, 356335, 356336, 356337

Fiber optic alignment methods and apparatus in accordance with the present invention first identify a target beam width incidence on an end of an optical element. The end of the optical element is placed into a beam of light at an axial location relative to the beam of light. The end of the optical element is subsequently moved transversally (perpendicular) to the beam of light until a position of maximum optical power, as measured through the optical element, is identified. A beam width of the beam of light is measured at that axial location. The movement and measurement sequence is repeated at multiple axial locations relative to the beam of light. Linear regression, or an equivalent approach is used, to predict an axial location relative to the beam of light with the target beam width. The end of the optical element is then moved to the axial location with the target beam width.

6806484, Oct 19, 2004

Aug 22, 2001

09/935018

Edward Steketee - Ft. Collins CO
John Bernard Medberry - Windsor CO
Benno Guggenheimer - Fort Collins CO

Agilent Technologies, Inc. - Palo Alto CA

G01N 2186

25055936, 25055929, 356622

An edge detector with sub-micron accuracy. The edge detector comprises two single mode optical fibers with an optical path between them. One fiber is coupled to a laser light source, and creates a light beam. The other fiber is coupled to an optical power detector. The optical power reaching the optical power detector is determined by how much of the light beam is obscured by an object. Thus the position of the edge of the object may be determined from the optical power measured by the detector. The edge of an object may be positioned automatically according to the optical power measured by the detector.

6493072, Dec 10, 2002

Sep 28, 2001

09/967453

John Medberry - Windsor CO
Benno Guggenheimer - Fort Collins CO
David Washburn - Fort Collins CO

Agilent Technologies, Inc. - Palo Alto CA

G01N 2100

356 731

A system and method for finding the position of a waveguide in a planar optical device that has application to the coupling of light to a planar optical waveguide without connectors. The system comprises input and output optical fiber probes, a light source, a photo or light detector and a optical power meter. The light detector is positioned at the exit of the optical waveguide of interest. Typically, the position of the waveguide will be known with some window of uncertainty. Assuming that the photo detector is a photodiode, the area of the photodiode is preferably large enough that the exit of the waveguide can be assumed to lie within the detection area of the photodiode. The input optical fiber probe is coupled to the light source and is moved across the uncertainty window of the entry to the waveguide. The light transmitted through the waveguide to the photo detector is measured and used to find the position of the entry to the way guide. The input fiber probe is then positioned at the entry to the waveguide.

2013008, Apr 4, 2013

Sep 24, 2012

13/625115

DAKO DENMARK A/S - Glostrup, DK
Marc Key - Ojai CA, US
John Favuzzi - Santa Barbara CA, US
Rosanne Welcher - Ventura CA, US
Benno Guggenheimer - Fort Collins CO, US
Robert Clark - Love Land CO, US
Michael Barber - Fort Collins CO, US
Bob Lathrop - San Jose CA, US

DAKO DENMARK A/S - Glostrup

G01N 1/30

435 611, 435 405, 435 71

Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (), sample carrier temperature regulation systems (), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

8298815, Oct 30, 2012

Dec 22, 2003

10/539562

Kristopher Buchanan - Fort Collins CO, US
Marc Key - Ojai CA, US
John Favuzzi - Santa Barbara CA, US
Rosanne Welcher - Ventura CA, US
Benno Guggenheimer - Fort Collins CO, US
Robert Clark - Loveland CO, US
Michael Barber - Fort Collins CO, US
Bob Lathrop - San Jose CA, US

DAKO Denmark A/S

C12M 1/34, C12M 3/00, C12M 1/00

4352873, 4353031, 435809, 414273, 414281, 414787, 422 63, 422 64, 422 65

Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (), sample carrier temperature regulation systems (), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

7648678, Jan 19, 2010

Dec 8, 2003

10/731316

John Favuzzi - Santa Barbara CA, US
Benno Guggenheimer - Fort Collins CO, US
Jeff Rau - Fort Collins CO, US
Marc Key - Ojai CA, US
Robert Lathrop - San Jose CA, US
Rosanne Welcher - Ventura CA, US

DAKO Denmark A/S - Glostrup

G01N 1/28, G01N 1/30

422 63, 422 65, 436 43, 436 47, 436 49, 436174, 435 405, 4352871, 4352873, 4352883

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

7758809, Jul 20, 2010

Dec 3, 2009

12/630665

John Favuzzi - Santa Barbara CA, US
Benno Guggenheimer - Fort Collins CO, US
Jeff Rau - Fort Collins CO, US
Marc Key - Ojai CA, US
Robert Lathrop - San Jose CA, US
Rosanne Welcher - Ventura CA, US

Dako Cytomation Denmark A/S

G01N 1/28, G01N 1/30

422 63, 422 65, 436 43, 436 47, 436 49, 436174, 435 405, 4352871, 4352873, 4352883

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

8216512, Jul 10, 2012

Dec 19, 2003

10/539308

Lars Winther - Smoerum, DK
Marc Key - Ojai CA, US
Kristopher S. Buchanan - Fort Collins CO, US
John Favuzzi - Santa Barbara CA, US
Benno Guggenheimer - Fort Collins CO, US

DAKO Denmark A/S

G01N 35/00

422 67, 422 681, 422 65, 422292, 422297, 422302, 435 405, 436 46, 436 47

The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.