Inventors:
Robert Vukovich - Holmdel NJ, US
Benjamin Levinson - Montgomery NJ, US
George S. Drummond - New York NY, US
Robert Caroselli - East Brunswick NJ, US
Kazimierz G. Antczak - Culver IN, US
Christopher Boucher - Newmarket CA, US
Richard Mortimer - Toronto, CA
Danny Levin - Toronto, CA
Keith A. Cooke - Milton CA, US
Assignee:
Infacare Pharmaceutical Corporation - Trevose PA
International Classification:
C07D 487/22
Abstract:
A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.