Inventors:
Jesus Gonzalez, III - Carlsbad CA, US
Dean Wilson - Bedford MA, US
Andreas Termin - Encinitas CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Yulian Zhang - Yardley PA, US
Benjamin Petzoldt - Bradenton FL, US
Lev T. D. Fanning - San Marcos CA, US
Timothy Neubert - San Diego CA, US
Roger Tung - Lexington MA, US
Esther Martinborough - San Diego CA, US
Nicole Hilgraf - San Diego CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 31/517, A61K 31/496, A61K 31/4523, A61P 19/02, A61P 25/06, A61P 25/08, A61P 29/02, A61P 35/00, C07D 401/04, C07D 403/04
US Classification:
5142661, 51426621, 51426622, 544283, 544284
Abstract:
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.