DR. BENJAMIN A TEPLY, MD
Osteopathic Medicine at 48 St, Omaha, NE
License number
Nebraska 4301096611
Category
Student, Health Care
Type
Student in an Organized Health Care Education/Training Program
License number
Nebraska 29950
Category
Osteopathic Medicine
Type
Medical Oncology
Address
Address
515 S 48Th St, Omaha, NE 68198
Phone
(402) 559-5600
(402) 559-6615 (Fax)
(402) 559-6615 (Fax)
Personal information
See more information about BENJAMIN A TEPLY at radaris.comName
Address
Phone
5109 Nicholas St, Omaha, NE 68132
5109 Nicholas St, Omaha, NE 68132
Professional information
See more information about BENJAMIN A TEPLY at trustoria.com
Polymers For Functional Particles
Polymers For Functional Particles
US Patent:
2013013, May 23, 2013
Filed:
Nov 9, 2012
Appl. No.:
13/673354
Inventors:
Massachusetts Institute of Technology - Cambridge MA, US
The Brigham and Women's Hospital, Inc. - Boston MA, US
Robert S. Langer - Newton MA, US
Benjamin A. Teply - Omaha NE, US
The Brigham and Women's Hospital, Inc. - Boston MA, US
Robert S. Langer - Newton MA, US
Benjamin A. Teply - Omaha NE, US
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
C08G 63/91, A61K 47/48
US Classification:
435188, 525 541
Abstract:
A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.
Polymers For Functional Particles
Polymers For Functional Particles
US Patent:
8367113, Feb 5, 2013
Filed:
May 15, 2007
Appl. No.:
11/803843
Inventors:
Frank X. Gu - Cambridge MA, US
Benjamin A. Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Benjamin A. Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 9/14, A61K 9/51
US Classification:
424489, 514883, 977773, 977906, 977915
Abstract:
The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates.
Polymers For Functional Particles
Polymers For Functional Particles
US Patent:
2010032, Dec 23, 2010
Filed:
Sep 1, 2010
Appl. No.:
12/873692
Inventors:
Frank X. Gu - Waterloo, CA
Benjamin A. Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
Benjamin A. Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Omid C. Farokhzad - Chestnut Hill MA, US
International Classification:
B32B 5/00
US Classification:
428402
Abstract:
The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
Aptamer-Directed Drug Delivery
Aptamer-Directed Drug Delivery
US Patent:
2011005, Mar 3, 2011
Filed:
May 17, 2007
Appl. No.:
12/301225
Inventors:
Omid C. Farokhzad - Chestnut Hill MA, US
Sangyong Jon - Gwangju, KR
Vaishali Bagalkot - Gwangju, KR
Liangfang Zhang - Cambridge MA, US
Benjamin Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Sangyong Jon - Gwangju, KR
Vaishali Bagalkot - Gwangju, KR
Liangfang Zhang - Cambridge MA, US
Benjamin Teply - Omaha NE, US
Robert S. Langer - Newton MA, US
Assignee:
GWANGJU INSTITUTE OF SCIENCE & TECHNOLOGY - Gwangju
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
International Classification:
A61K 9/14, C07H 21/04, A61K 31/7088, A61P 35/00
US Classification:
424486, 536 231, 514 44 R
Abstract:
The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.
System For Targeted Delivery Of Therapeutic Agents
System For Targeted Delivery Of Therapeutic Agents
US Patent:
2014001, Jan 16, 2014
Filed:
Jul 25, 2013
Appl. No.:
13/950804
Inventors:
Robert S. Langer - Newton MA, US
Benjamin A. Teply - Omaha NE, US
Stephen E. Zale - Hopkinton MA, US
Benjamin A. Teply - Omaha NE, US
Stephen E. Zale - Hopkinton MA, US
International Classification:
A61K 9/50, A61K 31/337
US Classification:
424497, 514449
Abstract:
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
System For Targeted Delivery Of Therapeutic Agents
System For Targeted Delivery Of Therapeutic Agents
US Patent:
2010026, Oct 21, 2010
Filed:
Sep 26, 2008
Appl. No.:
12/239136
Inventors:
Omid C. FAROKHZAD - Chestnut Hill MA, US
Jianjun CHENG - Champaign IL, US
Benjamin A. TEPLY - Omaha NE, US
Robert S. LANGER - Newton MA, US
Stephen E. ZALE - Hopkinton MA, US
Jianjun CHENG - Champaign IL, US
Benjamin A. TEPLY - Omaha NE, US
Robert S. LANGER - Newton MA, US
Stephen E. ZALE - Hopkinton MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
International Classification:
A61K 9/14, A61K 38/02, A61K 31/7088, A61K 31/70, A61K 39/395, A61K 38/43, A61K 31/713, A61K 51/12, A61K 39/00, A61K 49/04, A61K 49/18, A61K 31/337, A61P 35/00
US Classification:
424 129, 424486, 424487, 514 11, 514 44 R, 514 23, 4241301, 4241331, 424 941, 514 44 A, 4241841, 424 94, 424 93, 424423, 514449
Abstract:
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.