BEN Z STANGER
Broker in Brookline, MA

License number
Massachusetts 115593
Issued Date
Nov 1, 1979
Expiration Date
Aug 11, 2002
Type
Broker
Address
Address
Brookline, MA 02445
LicenseFiles verified this license of Nov 25, 2016 at the Mass.gov - Consumer Affairs and Business Regulation.

Professional information

Ben Stanger Photo 1

Cell Death Protein

US Patent:
5674734, Oct 7, 1997
Filed:
May 18, 1995
Appl. No.:
8/444005
Inventors:
Philip Leder - Chestnut Hill MA
Brian Seed - Boston MA
Ben Z. Stanger - Brookline MA
Tae-Ho Lee - Daejeon, KR
Emily Kim - Chestnut Hill MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
The General Hospital Corporation - Boston MA
International Classification:
C12N 120, C07H 2102, C07H 2104, C12P 2106
US Classification:
4352523
Abstract:
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.

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