BEATRIX ASTRID OLOFSSON
Medical Practice in Philadelphia, PA
License number
Pennsylvania MT190083
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
Philadelphia, PA 19118
Personal information
See more information about BEATRIX ASTRID OLOFSSON at radaris.comName
Address
Phone
1010 Crest Way APT 402, York, PA 17403
Professional information
See more information about BEATRIX ASTRID OLOFSSON at trustoria.com
Atm-Dependent Phosphorylation Of Sp1 Is Involved In The Cellular Response To Dna Damage And Enhances Cellular Survival After Dna Damage
Atm-Dependent Phosphorylation Of Sp1 Is Involved In The Cellular Response To Dna Damage And Enhances Cellular Survival After Dna Damage
US Patent:
8476025, Jul 2, 2013
Filed:
Aug 6, 2008
Appl. No.:
12/187187
Inventors:
Jane Clifford - Narberth PA, US
Beatrix A. Olofsson - Philadelphia PA, US
Crystal M. Kelly - Columbus OH, US
Beatrix A. Olofsson - Philadelphia PA, US
Crystal M. Kelly - Columbus OH, US
Assignee:
Philadelphia Health and Education Corporation - Philadelphia PA
International Classification:
G01N 33/53
US Classification:
435 71, 436518
Abstract:
The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO. : 2) at serine residue 101 (known herein as phosphoserineSp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.