BEATRIX ASTRID OLOFSSON
Medical Practice in Philadelphia, PA
License number
Pennsylvania MT190083
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
Philadelphia, PA 19118
Professional information
Atm-Dependent Phosphorylation Of Sp1 Is Involved In The Cellular Response To Dna Damage And Enhances Cellular Survival After Dna Damage
US Patent:
8476025, Jul 2, 2013
Filed:
Aug 6, 2008
Appl. No.:
12/187187
Inventors:
Jane Clifford - Narberth PA, US
Beatrix A. Olofsson - Philadelphia PA, US
Crystal M. Kelly - Columbus OH, US
Beatrix A. Olofsson - Philadelphia PA, US
Crystal M. Kelly - Columbus OH, US
Assignee:
Philadelphia Health and Education Corporation - Philadelphia PA
International Classification:
G01N 33/53
US Classification:
435 71, 436518
Abstract:
The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO. : 2) at serine residue 101 (known herein as phosphoserineSp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.