Barton Aron Kamen
Medical Practice in W Windsor Township, NJ
License number
New Jersey 25MA06892700
Issued Date
Jan 5, 1999
Expiration Date
Jun 30, 2013
Category
Medical Examiners
Type
Medical Doctor
Address
Address
W Windsor Township, NJ
Professional information
Compositions And Methods Employing Aminopterin
US Patent:
7612071, Nov 3, 2009
Filed:
Mar 9, 2005
Appl. No.:
11/078614
Inventors:
Barton Aron Kamen - Princeton Junction NJ, US
Peter David Cole - Montclair NJ, US
Angela King Smith - West Windsor NJ, US
John Anthony Zebala - Sammamish WA, US
Peter David Cole - Montclair NJ, US
Angela King Smith - West Windsor NJ, US
John Anthony Zebala - Sammamish WA, US
Assignee:
Syntrix Biosystems, Inc. - Auburn WA
International Classification:
A01N 43/54, A01N 43/60, A61K 31/4995, A61K 31/505
US Classification:
514249
Abstract:
The present invention relates to pharmaceutical compositions containing the antifolate aminopterin, processes for making the compositions, and methods of using them to treat disorders in adult and pediatric patients. Pharmaceutical compositions substantially free of impurities are provided comprising a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof. Relative to the teachings of the prior art, the disclosed methods and compositions provide unexpected improvements that include a greater interpatient oral bioavailability in pediatric patients, a smaller interpatient coefficient of variation of oral bioavailability, a smaller mean intrapatient coefficient of variation of oral bioavailability, a greater therapeutic index, a smaller coefficient of variation of toxicity, efficacy in combination therapy, and efficacy of certain polyglutamated metabolites.
Stable Solid Dosage Forms Of Aminopterin
US Patent:
2008005, Mar 6, 2008
Filed:
Oct 30, 2007
Appl. No.:
11/928257
Inventors:
Absar Faruqui - Auburn WA, US
John Zebala - Sammamish WA, US
Barton Kamen - Princeton Junction NJ, US
John Zebala - Sammamish WA, US
Barton Kamen - Princeton Junction NJ, US
Assignee:
Syntrix BIosystems, Inc. - Auburn WA
International Classification:
A61K 31/4985, A61P 35/00
US Classification:
514249000
Abstract:
There is disclosed stable pharmaceutical compositions containing pharmaceutically acceptable salts of aminopterin surface deposited onto solid excipients. The stable pharmaceutical compositions are hermetically sealed from the atmosphere. The formation of degradation products of aminopterin is reduced or eliminated.
Aminopterin Dosage Forms And Methods For Inflammatory Disorders
US Patent:
8129383, Mar 6, 2012
Filed:
Oct 30, 2007
Appl. No.:
11/928890
Inventors:
John Zebala - Sammamish WA, US
Barton A. Kamen - Princeton Junction NJ, US
Barton A. Kamen - Princeton Junction NJ, US
Assignee:
Aminopterin LLC - Auburn WA
International Classification:
A61K 31/505
US Classification:
514249, 514825, 514863, 514886, 514903
Abstract:
There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Specifically, there is disclosed a method for treating an inflammatory disorder in a patient with uninterrupted doses of aminopterin.