BARRY REISBERG, M.D.
Psychiatric in New York, NY

5150716, Sep 29, 1992

Jan 28, 1991

7/646688

Emile Franssen - New York NY
Barry Reisberg - New York NY

A61B 5103

128774

Deep tendon reflexes, plantar responses, muscle tone and release signs were studied as 14 individual clinical variables and as 5 summary variables in 135 aged subjects, including 27 controls, 20 subjects with mild cognitive impairment, and 88 subjects with successive stages of probable Alzheimer's disease (AD). Changes in activity of elicited responses were rated on a seven-point scale. Results were analyzed both as prevalence and mean degree of change in activity. Mild cognitive impairment was associated with a significantly higher rating than controls on a variable combining all 14 individual variables. Subjects with early AD had both higher prevalence of increased activity and increased mean scores of deep tendon reflexes and muscle tone. They had a higher prevalence of increased activity on a variable combining three release signs. Patients with late stage AD had significantly increased prevalence and mean scores of muscle tone, grasping and sucking reflexes compared with controls and early AD patients.

2009009, Apr 16, 2009

Jun 6, 2008

12/134768

Barry Reisberg - New York NY, US

G06F 19/00, A61B 10/00

702 19, 424 92

A method for the identification of treatments and preventative agents for brain aging, subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and other degenerative dementias, the method including (a) the identification of the diagnosis and stage of the subject, (b) the identification of the duration of the stage of the condition and/or disorder, (c) the identification of prognostic markers based upon a formula incorporating the duration of the condition and/or stage, (d) the prospective separation of prognostic subgroups based upon outcome wherein the outcome is defined in these conditions as progression to a subsequent stage or stages, (e) the employment of a putative prognostic marker for an appropriate period of time, based upon the formula incorporating the duration of the condition and/or stage, (f) the application of in vivo, methodology specific techniques, in conjunction with stage specific prognostic subgroups, for the appropriate time period, for the identification, prospectively, of useful markers, (g) the employment of these markers to identify useful therapeutic agents for prevention and treatment.

4385053, May 24, 1983

Mar 11, 1981

6/242750

Barry Reisberg - New York NY
Steven H. Ferris - Huntington NY

A61K 3140, A61K 31685

424199

A process is disclosed for treating human memory impairment associated with aging, such as occurs in Alzheimer's disease, by administering a central nervous system cholinergic precursor such as lecithin or a choline salt in construction with a metabolic enhancer such as piracetam.

7122006, Oct 17, 2006

Jul 31, 2003

10/632558

Barry Reisberg - New York NY, US
Stefanie R. Auer - Sulbach 102 Bad Ischl 4820, AT

A61B 5/00

600300, 128920

A method is provided for the care and treatment of AD and related dementias by staging patients using the FAST, BCRS, and/or the GDS staging elements, translation of the staging elements into corresponding developmental ages (DAs), using the patient DA to determine the overall management and care needs of patients with AD and related retrogenic dementias, refining these needs based upon axioms refined by postulates and caveats.

5782777, Jul 21, 1998

Jun 12, 1996

8/662062

Liduin E. M. Souren-Franssen - New York NY
Emil H. Franssen - New York NY
Barry Reisberg - New York NY

A61B 5103

600587

The clinical severity of Alzheimer's Disease in the elderly may be determined by measurement of contractures which correlate with the clinical severity of the disease. A goniometer may be used to determine the existence and degree of such contractures.

6067986, May 30, 2000

Oct 29, 1993

8/145984

Alan Kluger - Kew Gardens NY
John Gianutsos - Sunnyside NY
Barry Reisberg - New York NY

A61B 503

128782

A method for differentiating cognitively normal elderly individuals from mildly demented patients with Alzheimer's disease by monitoring motor/psychomotor test results by the use of various computer monitored transducer apparatus attached to the individual while the individual undergoes testing. Head tracking ability, head steadiness, EMG-Arm extension tracking, and joint position matching are measured parameters used in the method.

5082446, Jan 21, 1992

Jun 12, 1990

7/537921

Steven G. Sclan - New York NY
Barry Reisberg - New York NY

G09B 1900

434236

A method for the cognitive assessment of adult patients with severe dementia. The method proceeds by adapting cognitive assessment tests for infants to the special requirements of such patients.