Inventors:
Kumar Sharma - Del Mar CA, US
Barry Goldstein - Bala Cynwyd PA, US
Assignee:
THOMAS JEFFERSON UNIVERSITY - Philadelphia PA
International Classification:
A61K 38/17, C12Q 1/68, G01N 33/53, A61K 31/7088, G01N 33/00
US Classification:
514 12, 435 6, 435 71, 514 44 R, 436 86, 436 94
Abstract:
Disclosed are methods relating to the treatment and/or prevention of kidney disorders, especially kidney disorders characterized by or involving albuminuria. Methods described include the administration of an adiponectin polypeptide or a nucleic acid encoding such a polypeptide to treat or prevent the development of albuminuria. Also described are methods in which adiponectin is measured as a predictor of a subject's likelihood of having or developing a kidney disorder characterized by or involving albuminuria. Also described are methods of treating or preventing a kidney disorder involving administering an AMPK agonist and/or an inhibitor of Nox4 activity.