Inventors:
David A. Markovitz - Ann Arbor MI, US
Nirit Mor-Vaknin - Ann Arbor MI, US
Michael Khodadoust - Ann Arbor MI, US
Barbara S. Adams - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 39/395, A61K 31/7105, C12Q 1/68, G01N 33/535
US Classification:
4241411, 514 44, 4241301, 435 6, 435 792
Abstract:
The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides compositions and methods for treating autoimmune disease (e.g., juvenile rheumatoid arthritis, lupus, etc.) and for inhibiting inflammation (e.g., associated with autoimmune disease) and cellular chemotaxis (e.g., of neutrophils, NK cells and T cells). The present invention further provides a diagnostic marker (e.g., DEK antigen) for autoimmune disease.