BARBARA J BLANCHARD, LIC. AC.
Acupuncture at Pearl St, Cambridge, MA
License number
Massachusetts 404
Category
Acupuncture
Type
Acupuncturist
Address
Address
44 Pearl St, Cambridge, MA 02139
Phone
(617) 492-3798
Professional information
Barbara J Blanchard, Cambridge MA
Specialties:
Acupuncturist
Address:
44 Pearl St, Cambridge, MA 02139
Barbara J Blanchard, Cambridge MA - LICAC
Specialties:
Acupuncture
Address:
44 Pearl St, Cambridge 02139
(617) 492-3798 (Phone)
(617) 492-3798 (Phone)
Languages:
English
Methods For Identifying Treatments For Neurotoxicity In Alzheimer's Disease Caused By Β-Amyloid Peptides
US Patent:
6942963, Sep 13, 2005
Filed:
Nov 3, 2000
Appl. No.:
09/706574
Inventors:
Vernon M. Ingram - Cambridge MA, US
Barbara J. Blanchard - Cambridge MA, US
Barbara J. Blanchard - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12Q003/00
US Classification:
435 3, 435808, 436 63, 436164, 436172, 436182, 436800, 436805
Abstract:
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a β-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates.
Treatments For Neurotoxicity In Alzheimer's Disease Caused By .Beta. Amyloid Peptides
US Patent:
6172043, Jan 9, 2001
Filed:
Jan 9, 1998
Appl. No.:
9/005215
Inventors:
Vernon M. Ingram - Cambridge MA
Barbara J. Blanchard - Cambridge MA
Barbara J. Blanchard - Cambridge MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 3804, C07K 700
US Classification:
514 17
Abstract:
The invention involves identification of a mechanism of. beta. -amyloid peptide cytotoxicity, which enables treatment of conditions caused by. beta. -amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of. beta. -amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a. beta. -amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic. beta. -amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of. beta. -amyloid peptides and the neurotoxic effects of such aggregates.
Treatments For Neurotoxicity In Alzheimer's Disease
US Patent:
7101879, Sep 5, 2006
Filed:
Jan 18, 2002
Appl. No.:
10/051663
Inventors:
Vernon M. Ingram - Cambridge MA, US
Barbara J. Blanchard - Cambridge MA, US
Brent R. Stockwell - Boston MA, US
Barbara J. Blanchard - Cambridge MA, US
Brent R. Stockwell - Boston MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
Whitehead Institute for Biomedical Research - Cambridge MA
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A61S 31/535
US Classification:
5142315, 5142348, 5142345
Abstract:
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can reduce the neurotoxic effects of such aggregates. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates, such as Alzheimer's disease and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can reduce the neurotoxic effects of β-amyloid aggregates.
Treatments For Neurotoxicity In Alzheimer's Disease
US Patent:
7067550, Jun 27, 2006
Filed:
May 10, 2002
Appl. No.:
10/143534
Inventors:
Vernon M. Ingram - Cambridge MA, US
Barbara J. Blanchard - Cambridge MA, US
Brent R. Stockwell - Boston MA, US
Barbara J. Blanchard - Cambridge MA, US
Brent R. Stockwell - Boston MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 31/4035
US Classification:
514417
Abstract:
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can reduce the neurotoxic effects of such aggregates. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates, such as Alzheimer's disease and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can reduce the neurotoxic effects of β-amyloid aggregates.