Inventors:
Vince YEH - San Diego CA, US
Xiaolin LI - Emeryville CA, US
Xiaodong LIU - San Diego CA, US
Jon LOREN - San Diego CA, US
Valentina MOLTENI - San Diego CA, US
Juliet NABAKKA - San Diego CA, US
Bao NGUYEN - San Diego CA, US
Hank Michael James PETRASSI - Cardiff CA, US
International Classification:
A61K 31/437, A61K 31/496, A61K 31/5377, A61P 19/04, A61P 11/00, A61P 1/00, A61P 37/06, A61P 3/00, A61P 21/00, A61P 17/00, A61P 9/12, A61P 11/06, A61P 37/08, A61P 9/00, A61P 3/10, C07D 471/04
US Classification:
5142332, 546121, 514300, 544362, 51425304, 544127, 546 15
Abstract:
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.