Inventors:
Ralph R. Weichselbaum - Chicago IL, US
Donald W. Kufe - Wellesley MA, US
Bakhtiar Yamini - Chicago IL, US
Assignee:
THE UNIVERSITY OF CHICAGO - Chicago IL
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
A61K 51/00, C12N 5/09, A61K 38/19, A61K 31/4188, A61K 35/76, A61P 35/00
US Classification:
424 111, 435375, 424 851, 514393, 424 932
Abstract:
Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed are methods of synergistically inhibiting growth of a glioma in a human cancer patient comprising administering temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Pharmaceutical combinations and therapeutic combinations suitable for use in the methods of the invention are also disclosed.