AZORIDES R MORALES
Medical Practice in Miami, FL

6207408, Mar 27, 2001

Aug 19, 1998

9/136292

Ervin Essenfeld - Caracas, VE
Harold Essenfeld - Caracas, VE
Azorides Morales - Miami FL

University of Miami - Miami FL

G01N1/30

435 405

A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.

8221996, Jul 17, 2012

Mar 12, 2008

12/046465

Azorides Morales - Miami FL, US
Harold Essenfeld - Caracas, VE
Ervin Essenfeld - Caracas, VE

The University of Miami - Miami FL

G01N 1/30, G01N 33/48

435 405

A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.

7547538, Jun 16, 2009

Mar 27, 2003

10/400060

Azorides Morales - Miami FL, US
Harold Essenfeld - Caracas, VE
Ervin Essenfeld - Caracas, VE

The University of Miami - Miami FL

A01N 1/00

4352841

A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of nonaqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.

7526987, May 5, 2009

Apr 12, 2007

11/783806

Azorides R. Morales - Miami FL, US

The University of Miami - Miami FL

B26D 3/00, B23Q 1/00, G01N 1/00

83 13, 269 53

A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.

7470401, Dec 30, 2008

Oct 25, 2004

10/971700

Azorides R. Morales - Coral Gables FL, US

The University of Miami - Miami FL

G01N 21/00

422 65, 422 63, 422 64, 422 99, 422100, 436180, 427 4, 427296

Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.

7219884, May 22, 2007

Oct 1, 2002

10/260443

Azorides R. Morales - Miami FL, US

The University of Miami - Miami FL

B23Q 1/00

269 53

A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.

7138226, Nov 21, 2006

May 10, 2002

10/141780

Vladimir Vincek - Aventura FL, US
Mehdi Nassiri - Miami FL, US
Mehrdad Nadji - Miami FL, US
Azorides R. Morales - Coral Gables FL, US

The University of Miami - Miami FL

C12N 5/00

435 11, 435374, 436 18

A solution for preservation and/or storage of a cell or tissue is described. This simple nonaqueous composition can have 10% polyethylene glycol and 90% methanol. It can be used at room temperature. Special chemicals, equipment, and techniques are not needed. Tissue preserved with and/or stored in the solution can be processed for cytology or histology, including chemical staining and/or antibody binding, by a variety of methods; antigen, DNA, and RNA can be extracted from processed tissue in high yield and with minimal or no degradation. Advantages of the solution include: economy and safety, easy access to archival material, and compatibility with both cellular and genetic analyses. The use and manufacture of the solution are also described.