AYKUT UREN
Pilots at Ashley Dr, Rockville, MD
License number
Maryland A4780307
Issued Date
Jan 2017
Expiration Date
Jan 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
11804 Ashley Dr, Rockville, MD 20852
Professional information
Sfrp And Peptide Motifs That Interact With Sfrp And Methods Of Their Use
US Patent:
2004007, Apr 22, 2004
Filed:
Jul 10, 2003
Appl. No.:
10/466136
Inventors:
Jeffrey Rubin - Potomac MD, US
Aykut Uren - Rockville MD, US
Brian Kay - Hinsdale IL, US
Bernard Weisblum - Madison WI, US
Matthew Gillespie - Mount Waverly, AU
Nicole Horwood - Ashwood, AU
Aykut Uren - Rockville MD, US
Brian Kay - Hinsdale IL, US
Bernard Weisblum - Madison WI, US
Matthew Gillespie - Mount Waverly, AU
Nicole Horwood - Ashwood, AU
International Classification:
C07K007/06, C07K007/08
US Classification:
530/328000
Abstract:
This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.
Targeting Of Ews-Fli1 As Anti-Tumor Therapy
US Patent:
2010000, Jan 7, 2010
Filed:
Jun 29, 2009
Appl. No.:
12/494191
Inventors:
Jeffrey A. Toretsky - Silverspring MD, US
Aykut Uren - Rockville MD, US
Milton Lang Brown - Brookville MD, US
Yali Kong - Centreville VA, US
Aykut Uren - Rockville MD, US
Milton Lang Brown - Brookville MD, US
Yali Kong - Centreville VA, US
International Classification:
A61K 38/10, A61K 38/08, A61K 38/06, A61K 38/05, A61K 31/4439, A61K 31/404, C07K 7/08, C07K 7/06, C07K 5/10, C07D 401/06, C07D 209/32, A61P 35/00
US Classification:
514 14, 514 15, 514 18, 514 19, 514339, 514418, 530327, 530328, 530331, 5462777, 548485
Abstract:
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
Secreted Frizzled Related Protein, Sfrp, Fragments And Methods Of Use Thereof
US Patent:
2011017, Jul 21, 2011
Filed:
Feb 18, 2011
Appl. No.:
13/031060
Inventors:
JEFFREY S. RUBIN - POTOMAC MD, US
SUSAN CUMBERLEDGE - BELCHERTOWN MA, US
FRIEDA REICHSMAN - SHUTESBURY MA, US
AYKUT UREN - ROCKVILLE MD, US
SUSAN CUMBERLEDGE - BELCHERTOWN MA, US
FRIEDA REICHSMAN - SHUTESBURY MA, US
AYKUT UREN - ROCKVILLE MD, US
Assignee:
The Gov. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services - Bethesda MD
The University of Massachusetts - Amherst MA
The University of Massachusetts - Amherst MA
International Classification:
C12P 21/02, C07H 21/00, C12N 15/63, C12N 5/10, C12N 1/00
US Classification:
435 691, 536 235, 4353201, 435325, 435243, 435410
Abstract:
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.