Inventors:
Avtar S. Dhaliwal - Johnson City TN
Shabir Z. Masih - Johnson City TN
International Classification:
A61M 3100
Abstract:
An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2. 5 to about 6. 9, wherein the anesthetic comprises from about 0. 5 to about 2. 0% by weight of the composition, the composition further containing sufficient NaHCO. sub. 3 to maintain the pH thereof between about 7. 0 and about 7. 6, and further containing from about 0. 0004 moles of dissolved CO. sub. 2 per ml of composition up to the saturation level of dissolved CO. sub. 2 at a CO. sub. 2 head pressure of up to about 2. 5 atmospheres.