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Modulation Of The Immune Response Through The Manipulation Of Arginine Levels
US Patent:
2004005, Mar 25, 2004
Filed:
Mar 12, 2003
Appl. No.:
10/386131
Inventors:
Augusto Ochoa - New Orleans LA, US Juan Ochoa - Pittsburgh PA, US Mircea Popescu - Plainsboro NJ, US Arnold Zea - Metairie LA, US Paulo Rodriguez - Metairie LA, US
The present invention provides methods and compositions for modulating an immune response by controlling the level of arginase available to a cell, tissue or system. An immune response can be enhanced or depressed by altering the amount of arginine available to a cell, tissue or system through the manipulation of localized or systemic arginine levels using substances which provide arginine to the body and enzymes which break down arginine, such as arginase and nitric oxide synthase. Increasing or decreasing an immune response according to the present invention provides therapeutic treatments for a variety of conditions and diseases. The present invention also provides clinical methods and kits which can measure the strength or resistance to an immune response in a cell, tissue or system based upon the amount of available arginine and enzymes which break down arginine.
Methods For Treatment Of Ocular Diseases
US Patent:
2013034, Dec 26, 2013
Filed:
Mar 14, 2013
Appl. No.:
13/828669
Inventors:
Paulo Cesar Rodriguez - Metarie LA, US James Milton Hill - New Orleans LA, US Augusto Ochoa - New Orleans LA, US
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Raton Rouge LA
International Classification:
A61K 38/50
US Classification:
424 943
Abstract:
Methods and therapeutic treatments of ocular diseases are provided including applying peg-Arginase I to affected eyes. Methods are provided that simultaneously treat inflammation and neovascularization of eyes while promoting healing. Methods are provided to treat lesions or infections of an eye.