Inventors:
Audie Leventhal - Salt Lake City UT, US
International Classification:
A61K031/5513, A61K031/515, A61K031/19, A61K031/195
US Classification:
514/221000, 514/270000, 514/561000, 514/557000
Abstract:
Methods are disclosed for improving age-related decreases in cortical function by increasing the activity of inhibitory pathways, such as GABA-ergic pathways, in the central nervous system. In particular examples, subjects with age-related decreases in cortical function are treated by administering therapeutically effective amounts of a GABA-ergic agonist. The disclosed methods also enable screening for drugs that inhibit an age-related decline in cortical function, for example by exposing a subject to a test agent, and measuring an increase in GABA-ergic cortical inhibitory activity.