Inventors:
John Bartha - Rancho Palos Verdes CA, US
Lehel Balint - Rancho Palos Verdes CA, US
Gregory Zeltser - Irvine CA, US
Arthur Bunzel - Laguna Beach CA, US
Yin Tang - Los Angeles CA, US
International Classification:
A61K009/22
Abstract:
An implantable bioartificial active secretion system for providing a physiological secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host in fluidic communication with tissue fluid indicative of secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological secretion. A periodically operating pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the regulating physiological secretion for subsequent physiologically-effective dispensing into the host while avoiding immunorejection of the host body or of the host to the secretory cells.