ARNOLD MELMAN, MD
Urology at Park Ave, New York, NY

6271211, Aug 7, 2001

Mar 21, 2000

9/532138

George J. Christ - Smithtown NY
Arnold Melman - Ardsley NY

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

A01N 4304, A61K 3170, C12N 1500, C12N 1509, C12N 1563

514 44

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

7030096, Apr 18, 2006

Mar 21, 2000

09/531969

Jan Geliebter - Brooklyn NY, US
George J. Christ - Smithtown NY, US
Arnold Melman - Ardsley NY, US
Jamil Rehman - Bronx NY, US

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

A01N 43/04, A01N 63/00, A01N 65/00, A61K 31/70, C12N 15/00

514 44, 424 931, 4353201, 435325, 435455, 536 231

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

6007521, Dec 28, 1999

Jan 7, 1997

8/779562

Robert E. Bidwell - Melville NY
Arnold Melman - Ardsley NY

A61M 500

604264

A drainage catheter system including a catheter, a collection bag, and a collection bag saddle, is provided. The catheter includes a catheter body having an interior lumen, an elongate tubular sheath operatively associated with the catheter body, and a layer of lubricant disposed between the catheter body and the tubular sheath. The sheath is inflatable after deployment to provide sealing engagement with an inner wall of the urethra. One end of the catheter body is adapted to be connected to the collection bag which includes a fluid entry portion having a one-way fluid valve, a gas separation chamber, and a one-way gas valve. The collection bag also includes a main liquid reservoir in fluid communication with the fluid entry portion and a sealed drainage member for permitting drainage of the main liquid reservoir. The collection bag saddle facilitates attachment of the collection bag to a patient's body, and includes a main body portion, a plurality of mounting pads attached thereto including adhesive backings, and collection bag mounting structure formed in the main body portion.

7097622, Aug 29, 2006

May 21, 2004

10/851861

Clifford B. Bleustein - New York NY, US
Joseph Arezzo - Mahwah NJ, US
Arnold Melman - Ardsley NY, US

A61B 5/00, A61B 19/00

600555, 600557, 128898

A non-invasive quantitative somatosensory apparatus is provided for evaluating erectile dysfunctions and involves the applications to the glans penis of two different temperatures. If the patient is unable to differentiate the difference in temperature, a diagnosis of neurologic dysfunction can be made with greater than 90% reliability. The apparatus of this invention provides a relatively simple device to assess a patient's neurological response to therapies.

2009004, Feb 12, 2009

Jul 31, 2008

12/221181

Kelvin P. Davies - New York NY, US
Arnold Melman - Ardsley NY, US

C12Q 1/68, C12Q 1/02

435 6, 435 29

Assays are provided for erectile and bladder dysfunction and vascular health (e.g., cardiovascular disease, hypertension), where the assays detect the expression of one or more of the human Vcsa1 gene family. The assays are also useful for monitoring the efficacy of treatment of these disorders.

2009006, Mar 12, 2009

Nov 23, 2004

10/579705

George J. Christ - Lewisville NC, US
Kelvin Davies - New York NY, US
Arnold Melman - Ardsley NY, US

ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY - Bronx NY

A61K 45/00, A61K 31/7088, A61P 21/00, A61P 15/10

424 937, 514 44

The invention provides methods of regulating smooth muscle tone in a subject, comprising the introduction, into smooth muscle cells of the subject, of a DNA sequence encoding a potassium channel protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. The invention provides methods of gene transfer for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders.

5779670, Jul 14, 1998

May 31, 1995

8/455126

Robert E. Bidwell - Melville NY
Arnold Melman - Ardsley NY

A61M 500

604172

A urethral catheter assembly is disclosed which includes an elongate catheter body having an expandable retention balloon provided at a distal end thereof, and a progressively deployable lubricated sheath which encloses the exterior surface of the catheter body. Once deployed, the sheath permits relative movement of the catheter body relative to the urethra without causing discomfort or trauma to the patient.