ARNOLD JEROME FRIEDHOFF
Medical Practice in New York, NY
License number
Pennsylvania MD022139L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
New York, NY 10128
Pennsylvania
Pennsylvania
Personal information
See more information about ARNOLD JEROME FRIEDHOFF at radaris.comName
Address
Phone
1382 Lexington Ave, New York, NY 10128
Professional information
See more information about ARNOLD JEROME FRIEDHOFF at trustoria.com
Genetically Modified Tyrosine Hydroxylase And Uses Thereof
Genetically Modified Tyrosine Hydroxylase And Uses Thereof
US Patent:
5300436, Apr 5, 1994
Filed:
Jan 26, 1993
Appl. No.:
8/009075
Inventors:
Menek Goldstein - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY
Assignee:
New York University - New York NY
International Classification:
C12N 1500, C12N 904
US Classification:
4352523
Abstract:
Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.
Psychosis Protecting Nucleic Acid, Peptides, Compositions And Method Of Use
Psychosis Protecting Nucleic Acid, Peptides, Compositions And Method Of Use
US Patent:
5962664, Oct 5, 1999
Filed:
Feb 23, 1996
Appl. No.:
8/602716
Inventors:
Arnold J. Friedhoff - New York NY
Daryl A. Basham - St. Albans NY
Jeannette C. Miller - New York NY
Daryl A. Basham - St. Albans NY
Jeannette C. Miller - New York NY
International Classification:
C07H 2104, C12N 1563, C12N 1585, C07K 1400
US Classification:
536 231
Abstract:
Psychosis protecting (PP) nucleic acids and encoded PP peptides and related proteins, and antibodies, anti-idiotype antibodies, and fragments thereto, for treatment, diagnosis and/or research related to the protection from psychosis such as schizophrenia or related disorders, or symptoms thereof, and expression products, compositions and methods therefor, including treatment of schizophrenia and related disorders, as well as transgenic non-human mammals epxressing PP peptide or related protein encoding nucleic acids.
Genetically Modified Tyrosine Hydroxylase And Uses Thereof
Genetically Modified Tyrosine Hydroxylase And Uses Thereof
US Patent:
5212082, May 18, 1993
Filed:
Mar 13, 1991
Appl. No.:
7/669446
Inventors:
Menek Goldstein - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY
Jing Wu - New York NY
David Filer - New York NY
Arnold J. Friedhoff - New York NY
Assignee:
New York University - New York NY
International Classification:
C12N 904, C12N 1500
US Classification:
435190
Abstract:
Modification of the DNA encoding the enzyme tyrosine hydroxylase (TH) resulting in amino acid substitution in one of the first fifty five N-terminal residues, in particular replacing Ser-40 with Tyr or Leu, produced TH variants having substantially increased enzymatic activity upon transfection of suitable host cells. Cells transfected with the variant TH having enhanced enzymatic activity are useful for treating neurological or psychiatric disorders associated with deficient TH or dopamine, in particular Parkinson's disease, by grafting such cells into the brain.