ARNOLD IRVING LEVINSON
Medical Practice in Delaware
License number
Pennsylvania MD021562E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Wayne, PA 19087
Wayne, PA 19087
Professional information
Vaccines For Suppressing Ige-Mediated Allergic Disease And Methods For Using The Same
US Patent:
2006005, Mar 9, 2006
Filed:
Jun 20, 2003
Appl. No.:
10/518701
Inventors:
Arnold Levinson - Radnor PA, US
Sandra Calarota - Philadelphia PA, US
David Weiner - Merion PA, US
Miguel Otero - San Juan PR, US
Sandra Calarota - Philadelphia PA, US
David Weiner - Merion PA, US
Miguel Otero - San Juan PR, US
International Classification:
A61K 48/00, C07H 21/02, C07H 21/04
US Classification:
536023100, 514044000
Abstract:
Nucleic acid molecules that encode a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines, vectors and host cells that comprise such nucleic acid molecules are disclosed. Isolated proteins, including haptenized proteins, comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise and methods of making such proteins and antibodies that specifically bind to such proteins are disclosed. Killed or inactivated cells or particles, including haptenized killed or inactivated cells or particles, that comprise a protein comprising at least one epitope of membrane IgE free of epitopes present on the serum IgE, including proteins that further comprise non-IgE T cell helper epitope are disclosed. Vaccines that comprise such killed or inactivated cells or particles are disclosed. Methods of treating and preventing IgE mediated allergic disease or condition are disclosed.