Inventors:
Arlene Stecenko - Atlanta GA, US
Kenneth Birgham - Atlanta GA, US
Mauricio Rojas - Atlanta GA, US
International Classification:
A61K038/17, C07H021/04, A61L009/04, C12P021/04, C07K014/705
US Classification:
424/045000, 514/012000, 435/069700, 435/320100, 435/325000, 530/350000, 536/023500
Abstract:
The present invention provides a method of treating cystic fibrosis in a human subject diagnosed with cystic fibrosis, comprising administering to the subject, in a pharmaceutically acceptable carrier, an effective amount of a fusion protein, comprising a cystic fibrosis transmembrane conductance regulator (CFTR) and a membrane translocation sequence (MST), whereby the fusion protein can be taken up by affected cells in the subject, thereby treating cystic fibrosis. The present invention also provides a fusion protein comprising a cystic fibrosis transmembrane conductance regulator and a membrane translocation sequence.