Inventors:
Arleen Rifkind - New York NY, US
J. David Warren - New York NY, US
Erin Hall - Fort Mitchell KY, US
Yuliang Ma - New York NY, US
International Classification:
A61K 31/437, C12N 5/071, A61P 3/00, A61K 31/4745, C07D 471/04, A61P 35/00
US Classification:
514280, 546 87, 514292, 435375
Abstract:
We have found that exposure of an aqueous tryptophan solution to window sunlight results in the production of multiple tryptophan photoproducts that have the capability of activating the aryl hydrocarbon receptor and increasing the production of AhR target genes and proteins in hepatocytes. We have isolated three of those photoproducts not previously identified as AhR activators, their chemical identification and synthesis and the demonstration that all three have biologic activities as novel AhR activators. Further, one of the three is a completely novel, not previously described, chemical compound.