ANTHONY SAPIENZA
Medical Practice in West Chester, PA
License number
Pennsylvania MT186749
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
West Chester, PA 19380
Personal information
See more information about ANTHONY SAPIENZA at radaris.comName
Address
Phone
1207 Clearbrook Rd, West Chester, PA 19380
221 Amabell St, Pittsburgh, PA 15211
301 Bigham St, Pittsburgh, PA 15211
447 Pearce Rd, Pittsburgh, PA 15234
1001 Pine St #0503, Philadelphia, PA 19107
Professional information
See more information about ANTHONY SAPIENZA at trustoria.com
Substituted Thiazoles And The Use Thereof As Inhibitors Of Plasminogen Activator Inhibitor-1
Substituted Thiazoles And The Use Thereof As Inhibitors Of Plasminogen Activator Inhibitor-1
US Patent:
6586453, Jul 1, 2003
Filed:
Apr 2, 2001
Appl. No.:
09/822351
Inventors:
Dale S. Dhanoa - Laguna Niguel CA
Declan E. Ryan - West Chester PA
Ingrid Deckman - Berwyn PA
Anthony Sapienza - West Chester PA
Declan E. Ryan - West Chester PA
Ingrid Deckman - Berwyn PA
Anthony Sapienza - West Chester PA
Assignee:
3-Dimensional Pharmaceuticals, Inc. - Exton PA
International Classification:
A61K 31425
US Classification:
514365, 514369
Abstract:
The present invention relates to the use of aminothiazole derivatives of Formula I of as inhibitors of PAI-1, and to novel classes of aminothiazole derivatives, their synthesis and their use as inhibitors of PAI-1. It has been discovered that compounds of Formula I: or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein Y, Ar , Ar , R , R , Z, m and n are described in the specification, inhibit plasminogen activator inhibitor-1 (PAI-1). These compounds can be used in the prophylaxis or for the treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke.
Substituted Thiazoles And The Use Thereof As Inhibitors Of Plasminogen Activator Inhibitor-1
Substituted Thiazoles And The Use Thereof As Inhibitors Of Plasminogen Activator Inhibitor-1
US Patent:
2003022, Nov 27, 2003
Filed:
Apr 22, 2003
Appl. No.:
10/419970
Inventors:
Dale Dhanoa - Laguna Niguel CA, US
Declan Ryan - West Chester PA, US
Ingrid Deckman - Berwyn PA, US
Anthony Sapienza - West Chester PA, US
Declan Ryan - West Chester PA, US
Ingrid Deckman - Berwyn PA, US
Anthony Sapienza - West Chester PA, US
Assignee:
3-Dimensional Pharmaceuticals, Inc.
International Classification:
A61K031/426
US Classification:
514/370000
Abstract:
The present invention relates to the use of aminothiazole derivatives of Formula I of as inhibitors of PAI-1, and to novel classes of aminothiazole derivatives, their synthesis and their use as inhibitors of PAI-1. It has been discovered that compounds of Formula I:
or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein Y, Ar, Ar, R, R, Z, m and n are described in the specification, inhibit plasminogen activator inhibitor-1 (PAI-1). These compounds can be used in the prophylaxis or for the treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke.
Electrocatalyst Compositions
Electrocatalyst Compositions
US Patent:
6284402, Sep 4, 2001
Filed:
Jun 4, 1999
Appl. No.:
9/326206
Inventors:
Thomas E. Mallouk - State College PA
Benny C. Chan - State College PA
Erik Reddington - Woburn MA
Anthony Sapienza - West Chester PA
Guoying Chen - State College PA
Eugene Smotkin - Chicago IL
Bogdan Gurau - Chicago IL
Rameshkrishnan Viswanathan - Chicago IL
Renxuan Liu - Chicago IL
Benny C. Chan - State College PA
Erik Reddington - Woburn MA
Anthony Sapienza - West Chester PA
Guoying Chen - State College PA
Eugene Smotkin - Chicago IL
Bogdan Gurau - Chicago IL
Rameshkrishnan Viswanathan - Chicago IL
Renxuan Liu - Chicago IL
Assignee:
The Penn State Research Foundation - University Park PA
The Illinois Institute of Technology - Chicago IL
The Illinois Institute of Technology - Chicago IL
International Classification:
H01M 486, H01M 490, H01M 496, H01M 458
US Classification:
429 40
Abstract:
Compositions for use as catalysts in electrochemical reactions are described. The compositions are alloys prepared from two or more elemental metals selected from platinum, molybdenum, osmium, ruthenium, rhodium, and iridium. Also described are electrode compositions including such alloys and electrochemical reaction devices including such catalysts.
Pyrrolidine Sulfonamides
Pyrrolidine Sulfonamides
US Patent:
2004013, Jul 15, 2004
Filed:
Sep 26, 2003
Appl. No.:
10/472976
Inventors:
Dashyant Dhanak - King of Prussia PA, US
Steven Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph Rivero - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
Steven Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph Rivero - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
International Classification:
A61K031/496, C 07D 4 9/14
US Classification:
514/252130, 514/253100, 544/360000
Abstract:
The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
Pyrrolidine Sulfonamides
Pyrrolidine Sulfonamides
US Patent:
2004008, Apr 29, 2004
Filed:
Sep 26, 2003
Appl. No.:
10/472982
Inventors:
Dashyant Dhanak - King of Prussia PA, US
Steven Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph Rivera - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
Steven Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph Rivera - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
International Classification:
A61K031/55, A61K031/496, C 07D 4 3/14
US Classification:
514/217050, 514/253060, 514/253090, 514/253100, 544/360000, 544/363000
Abstract:
The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
Pyrrolidine Sulfonamides
Pyrrolidine Sulfonamides
US Patent:
7019008, Mar 28, 2006
Filed:
Apr 29, 2005
Appl. No.:
11/119026
Inventors:
Dashyant Dhanak - King of Prussia PA, US
Steven D. Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph A. Rivero - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
Steven D. Knight - King of Prussia PA, US
Jian Jin - King of Prussia PA, US
Ralph A. Rivero - King of Prussia PA, US
Anthony Sapienza - West Chester PA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/496, C07D 409/14
US Classification:
51425311, 514218, 51425401, 540575, 544364, 544372
Abstract:
A compound of Formula (I):
wherein:.