Inventors:
David Shima - Barnet, GB
Anthony Adamis - Bronxville NY, US
Gregory Robinson - Wilmington MA, US
Yin-Shan Ng - North Billerica MA, US
Kazuaki Nishijima - Arlington MA, US
Dominik Krilleke - Arlington MA, US
International Classification:
C07K 14/475, C07H 21/04, C12P 21/06, A61K 38/18
US Classification:
435069100, 514012000, 435320100, 435325000, 530399000, 536023500
Abstract:
Applicants have defined the pro-inflammatory domain of the Vascular Endothelial Growth Factor VEGF164(165) protein molecule using VEGF164 protein mutants in which the heparin binding domain is inactivated through alanine scanning, site directed mutagenesis. The invention provides novel VEGF variants having a modified heparin binding domain. The VEGF variants modified heparin binding function compared to native VEGF while maintaining receptor binding function. The invention provides compositions and methods for treating disorders relating to angiogenesis and inflammation.