Inventors:
Paul Sweetnam - Marblehead MA, US
Alessandra Bartolozzi - Norwalk CT, US
Anthony Stewart Campbell - Framingham MA, US
Bridget Cole - Quincy MA, US
Hope Foudoulakis - Framingham MA, US
Brian Kirk - Sudbury MA, US
Hemalatha Seshadri - Waltham MA, US
Siya Ram - Winchester MA, US
International Classification:
A61K 31/551, C07D 239/94, A61P 3/08, C07D 413/14, C07D 243/08, A61P 3/04, A61K 31/517, A61K 31/5377
US Classification:
514218, 51426623, 544293, 5142345, 544119, 51425217, 540575
Abstract:
The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins.