Inventors:
Scott X. Atwood - Stanford CA, US
Anthony Oro - Stanford CA, US
International Classification:
A61K 38/10, A61P 35/00, C12N 15/113, C07K 7/08, C12N 5/09, C07D 403/12, A61K 31/4355, C07D 491/107, A61K 31/45, C07D 211/40, A61K 31/713, A61K 31/496
US Classification:
514 195, 514 193, 514 44 A, 536 245, 530327, 51425405, 544371, 514278, 546 15, 514328, 546219, 435375
Abstract:
Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.