ANTHONY DWIGHT LOPES
Veterinary in Hopewell Township, NJ
License number
Pennsylvania BV004798L
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
2
Hopewell Township, NJ 08525
Pennsylvania
Pennsylvania
Personal information
See more information about ANTHONY DWIGHT LOPES at radaris.comName
Address
Phone
1067 Torremolinos Ct, Toms River, NJ 08753
583 Monmouth Ave, Belford, NJ 07718
641 Garland St, Philadelphia, PA 19120
79 Highland Blvd, Keansburg, NJ 07734
113 Flag Point Rd, Toms River, NJ 08753
Professional information
See more information about ANTHONY DWIGHT LOPES at trustoria.com
Amine Derivatives Of Anthracycline Antibodies
Amine Derivatives Of Anthracycline Antibodies
US Patent:
5162512, Nov 10, 1992
Filed:
May 27, 1988
Appl. No.:
7/199549
Inventors:
H. Dalton King - Yardley PA
Anthony D. Lopes - Hopewell NJ
Robert D. Radcliffe - Titusville NJ
John D. Rodwell - Yardley PA
Daniel J. Coughlin - Robbinsville NJ
Anthony D. Lopes - Hopewell NJ
Robert D. Radcliffe - Titusville NJ
John D. Rodwell - Yardley PA
Daniel J. Coughlin - Robbinsville NJ
Assignee:
Cytogen Corporation - Princeton NJ
International Classification:
C07H 1524
US Classification:
536 64
Abstract:
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to anthracycline antibiotic conjugates which retain substantial immunospecificity of the unconjugated antibody molecule. Using the conjugates, targeted delivery of the attached antibiotics is achieved in vivo. Such conjugates are thus therapeutically effective against a variety of neoplastic cellular disorders when administered in vivo. Methods for preparing the antibody conjugates and for use of the conjugates in vivo are also disclosed.
Amine Derivatives Of Anthracycline Antibiotics
Amine Derivatives Of Anthracycline Antibiotics
US Patent:
4950738, Aug 21, 1990
Filed:
Jun 5, 1987
Appl. No.:
7/058440
Inventors:
H. Dalton King - Yardley PA
Anthony D. Lopes - Hopewell NJ
Robert D. Radcliffe - Titusville NJ
John D. Rodwell - Yardley PA
Daniel J. Coughlin - Robbinsville NJ
Anthony D. Lopes - Hopewell NJ
Robert D. Radcliffe - Titusville NJ
John D. Rodwell - Yardley PA
Daniel J. Coughlin - Robbinsville NJ
Assignee:
Cytogen Corporation - Princeton NJ
International Classification:
C07H 1524
US Classification:
530322
Abstract:
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to prepare site-selectively attached therapeutic antibody-anthracyline antibiotic conjugates which retain substantial immunospecificity of the unconjugated antibody molecule. Using the conjugates, targeted delivery of the attached antineoplastic amine derivatives of anthracycline antibiotics is achieved in vivo. Such conjugates are thus therapeutically effective against a variety of neoplastic cellular disorders when administered in vivo. Methods for preparing the antibody conjugates and for use of the conjugates in vivo are also disclosed.