Inventors:
Richard Gatti - Los Angeles CA, US
Shareef A. Nahas - Los Angeles CA, US
Anthony W. Butch - Los Angeles CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 1/68
Abstract:
The present disclosure relates to methods for performing an assay to identify ataxia-telangiectasia homozygotes or heterozygotes. Some embodiments include the use of a rapid flow cytometry-based ataxiatelangiectasia (ATM) kinase assay that measures ATM-dependent phosphorylation of SMC1 following DNA damage.