Inventors:
Anne DeGroot - Providence RI, US
International Classification:
A61K039/29, A61K039/21, C07K014/16
Abstract:
The invention provides Cross-clade candidates that have “evolved” due to gene shuffling in vitro for inclusion of “cross-clade” characteristics. The invention also provides a method for identifying Cross-clade candidates that could be presented in the context of more than one HLA, due to the creation of promiscuous epitopes by gene shuffling.