Inventors:
Anne Moscona - New York NY, US
Matteo Porotto - New York NY, US
David LaVan - Rockville MD, US
Feng Yi - Rockville MD, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 9/14, A01N 25/26, A61K 38/04, C12N 7/06, A01P 1/00, A61P 31/12, A61P 31/14, A01N 37/18, A01N 25/08
US Classification:
424417, 514 37, 424490, 424409, 435238
Abstract:
The invention provides a method of reducing viral infectivity in a sample compnsing contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at least one virus-specific agent is attached to the lipids The virus-specific agent is capable of binding to at least one viral component The virus specific agent may be a receptor The earner matrix may be a silica particle, which may be coated with a lipid bilayer The invention further provides a method of inactivating a virus comprising contacting the virus with a earner matrix wherein lipids are attached to the earner matrix, and wherein at least one receptor is attached to the lipids, binding the receptor to at least one viral receptor-binding protein, and activating at least one viral fusion protein, wherein activation inactivates the virus, and releases the virus from the earner matrix