Inventors:
Pingbo Zhang - Ellicott City MD, US
Jennifer E. Van Eyk - Baltimore MD, US
Anne M. Murphy - Towson MD, US
Ger Stienen - Abcoude, NL
Jolanda van der Velden - Amsterdam, NL
Viola Kooij - Alphen, NL
Assignee:
VU-VUMC IP MANAGEMENT BV - Amsterdam NL
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
G01N 33/68
US Classification:
4241721, 435 71, 5303898, 5303882, 5303913, 977774
Abstract:
This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.