Inventors:
ANNA GREKA - Milton MA, US
International Classification:
A61K 49/00, A61K 39/395, A61K 39/00, A61K 31/713, A61P 13/12, G01N 33/53
US Classification:
424 92, 4241301, 4241841, 514 44 A, 435 721
Abstract:
It has been discovered that TRPC5 activity abolishes actin stress fibers and diminishes focal adhesion formation, rendering a motile, migratory podocyte phenotype. This invention relates generally to methods of reducing expression or activity of TRPC5 to treat, or reduce risk of developing, kidney disease, e.g., proteinuria, in a subject.